Chelsea will be without the suspended Ashley Cole after the England left-back was sent off against Swansea and Didier Drogba is still at the Africa Cup of Nations.
Brazilian midfielder Ramires damaged knee ligaments in the FA Cup win over QPR and is continuing his rehabilitation.
He joins Jon Obi Mikel on the sidelines, while Frank Lampard could return despite missing the draw at Swansea.
United have a decision to make in goal after Anders Lindegaard was ruled out for at least four weeks with an ankle ligament injury.
Ben Amos started in Tuesday's win over Stoke and could keep his place despite David de Gea's expected return to fitness.
Ferguson hopes Wayne Rooney, Nani, Tom Cleverley and Ashley Young could all be fit enough to return to the squad.
Long-term absentee Cleverley will travel to London with United's squad, but he is more likely to face Chelsea's reserves on Monday.
Possible starting XIs
Chelsea: Cech, Ivanovic, Terry, Luiz, Ferreira, Malouda, Romeu, Meireles, Mata, Sturridge, Torres.
Manchester United: De Gea, Smalling, Ferdinand, Evans, Evra, Park, Giggs, Carrick, Valencia, Welbeck, Rooney.
Man United: WLLWWW
Chelsea: Ramires, Lampard, Mikel
Man United: Lindegaard, Rooney, Nani, Cleverley, Young, Owen, Vidic
Man United: None
Referee: H Webb